PPM1L Antibody (PACO63111)
- SKU:
- PACO63111
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PPM1L Antibody (PACO63111) |
| Antibody SKU: | PACO63111 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein phosphatase 1L protein (128-343AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63111 diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. |
| Synonyms: | Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon), PPM1L, PP2CE |
| UniProt Protein Function: | PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.1Cellular Component: endoplasmic reticulum membraneMolecular Function: protein serine/threonine phosphatase activityBiological Process: sphingolipid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q5SGD2 |
| NCBI GenInfo Identifier: | 74743437 |
| NCBI Gene ID: | 151742 |
| NCBI Accession: | Q5SGD2.1 |
| UniProt Secondary Accession: | Q5SGD2,Q2M3J2, Q96NM7 |
| UniProt Related Accession: | Q5SGD2 |
| Molecular Weight: | 22,475 Da |
| NCBI Full Name: | Protein phosphatase 1L |
| NCBI Synonym Full Names: | protein phosphatase, Mg2+/Mn2+ dependent 1L |
| NCBI Official Symbol: | PPM1L |
| NCBI Official Synonym Symbols: | PP2CE; PPM1-LIKE; PP2C-epsilon |
| NCBI Protein Information: | protein phosphatase 1L |
| UniProt Protein Name: | Protein phosphatase 1L |
| UniProt Synonym Protein Names: | Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon |
| Protein Family: | Protein phosphatase |
| UniProt Gene Name: | PPM1L |
| UniProt Entry Name: | PPM1L_HUMAN |
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