PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)
![PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58352/63534/ppm1a-monoclonal-antibody-pp6c7at-cpab0126__60327__11745.1706534981.jpg?c=1 "PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)")
- SKU:
- CPAB0126
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- Pp6c7AT
- Applications:
- WB
- Applications:
- ELISA
![PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58352/63534/ppm1a-monoclonal-antibody-pp6c7at-cpab0126__60327__11745.1706534981.jpg?c=1&imbypass=on "PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)")
Description
system_update_alt Datasheet
| Product Name: | PPM1A Antibody |
| Product Sku: | CPAB0126 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PPM1A mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPM1A amino acids 1-382 purified from Ecoli. |
| Clone: | Pp6c7AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | PPM1A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | Protein Phosphatase 2C alpha is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described. Protein phosphatase 2C(PP2Cα) is a Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response in eukaryotes. |
| Synonyms: | Protein phosphatase 1A, EC 3.1.3.16, Protein phosphatase 2C isoform alpha, PP2C-alpha, IA, PPM1A, PP2CA, MGC9201. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
Related Products
PPM1A Monoclonal Antibody
OverviewProduct Name:PPM1A Monoclonal AntibodyProduct Code:CAB22076Reactivity:HumanApplications:Western blotting
SPAM1 Monoclonal Antibody
OverviewProduct Name:SPAM1 Monoclonal AntibodyProduct Code:CAB22178Reactivity:Human, Mouse, RatApplications:Western blotting, Imm
PMS2 Monoclonal Antibody
OverviewProduct Name:PMS2 Monoclonal AntibodyProduct Code:CAB22350Reactivity:HumanApplications:Western blotting
ACSL3 Monoclonal Antibody
OverviewProduct Name:ACSL3 Monoclonal AntibodyProduct Code:CAB22085Reactivity:Human, Mouse, RatApplications:Western blotting, Imm