PPM1A Monoclonal Antibody
- SKU:
- CAB22076
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PPM1A Monoclonal Antibody |
| Product Code: | CAB22076 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55164 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:20000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, A-431 |
| Cellular Location: | Cytoplasm, Lipid-anchor, Membrane, Nucleus, cytosol |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PPM1A (NP_066283.1). |
| Sequence: | MGAFL DKPKM EKHNA QGQGN GLRYG LSSMQ GWRVE MEDAH TAVIG LPSGL ESWSF FAVYD GHAGS QVAKY CCEHL LDHIT NNQDF KGSAG APSVE NVKNG IRTGF LEIDE HMRVM SEKKH GADRS GSTAV GVLIS PQHTY FINCG DSRGL LCRNR KVHFF TQDHK PSNPL EKERI QNAGG SVMIQ RVNGS LAVSR ALGDF DYKCV HGKGP TEQLV SPEPE VHDIE RSEED DQFII LACDG IWDVM GNEEL CDFVR SRLEV TDDLE KVCNE VVDTC LYKGS RDNMS VILIC FPNAP KVSPE AVKKE AELDK YLECR VEEII KKQGE GVPDL VHVMR TLASE NIPSL PPGGE LASKR NVIEA VYNRL NPYKN DDTDS TSTDD MW |
| Synonyms: | PP2CA, PP2Calpha, PP2C-ALPHA |
| Calculated MW: | 42kDa |
| Observed MW: | 43kDa |
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