POU6F2 Antibody (PACO20265)
- SKU:
- PACO20265
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | POU6F2 Antibody (PACO20265) |
| Antibody SKU: | PACO20265 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human POU6F2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20265(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: Mouse heart tissue, Primary antibody: PACO20265(POU6F2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20265(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. |
| Synonyms: | POU class 6 homeobox 2 |
| UniProt Protein Function: | POU6F2: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA. Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5). WT5 is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. Belongs to the POU transcription factor family. Class- 6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; Cell development/differentiation; Transcription factorChromosomal Location of Human Ortholog: 7p14.1Cellular Component: nucleusMolecular Function: transcription factor activityBiological Process: central nervous system development; ganglion mother cell fate determination; regulation of transcription, DNA-dependent; visual perceptionDisease: Wilms Tumor 5 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P78424 |
| NCBI GenInfo Identifier: | 327478564 |
| NCBI Gene ID: | 11281 |
| NCBI Accession: | P78424.3 |
| UniProt Secondary Accession: | P78424,P78425, Q75ME8, Q86UM6, Q9UDS7, A4D1W2, C4AMB9 |
| UniProt Related Accession: | P78424 |
| Molecular Weight: | 69,248 Da |
| NCBI Full Name: | POU domain, class 6, transcription factor 2 |
| NCBI Synonym Full Names: | POU class 6 homeobox 2 |
| NCBI Official Symbol: | POU6F2 |
| NCBI Official Synonym Symbols: | WT5; WTSL; RPF-1 |
| NCBI Protein Information: | POU domain, class 6, transcription factor 2 |
| UniProt Protein Name: | POU domain, class 6, transcription factor 2 |
| UniProt Synonym Protein Names: | Retina-derived POU domain factor 1; RPF-1 |
| Protein Family: | POU domain, class 6, transcription factor |
| UniProt Gene Name: | POU6F2 |
| UniProt Entry Name: | PO6F2_HUMAN |
Related Products
SPEF2 Antibody
Overview Product Name:SPEF2 AntibodyProduct Code:PACO64977Size:50µLTarget Names:SPEF2Species Reactivity:HumanHos
ompF Antibody
Overview Product Name:ompF AntibodyProduct Code:PACO64865Size:50µLTarget Names:ompFSpecies Reactivity:Escherichia coli
Hmgb1 Antibody
Overview Product Name:Hmgb1 AntibodyProduct Code:PACO64769Size:50µLTarget Names:Hmgb1Species Reactivity:RatHost
RIMS4 Antibody
Overview Product Name:RIMS4 AntibodyProduct Code:PACO64925Size:50µLTarget Names:RIMS4Species Reactivity:HumanHos
C22orf39 Antibody
Overview Product Name:C22orf39 AntibodyProduct Code:PACO64621Size:50µLTarget Names:C22orf39Species Reactivity:Human<