Porcine IL 8 Recombinant Protein (RPPB1163)
- SKU:
- RPPB1163
- Product Type:
- Recombinant Protein
- Species:
- Pig
- Uniprot:
- P26894
Description
| Product Name: | Porcine IL 8 Recombinant Protein |
| Product Code: | RPPB1163 |
| Size: | 20µg |
| Species: | Porcine |
| Target: | IL 8 |
| Synonyms: | IL-8, CXCL8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil-activating peptide, MONAP, Emoctakin, K60, NAF, LECT, LUCT, 3-10C, LYNAP, SCYB8, TSG-1, AMCF-I, b-ENAP, Alveolar macrophage chemotactic factor I. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 8 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | ARVSAELRCQ CINTHSTPFH PKFIKELRVI ESGPHCENSE IIVKLVNGKE VCLDPKEKWV QKVVQIFLKR TEKQQQQQ |
| Biological Activity: | The biological activity was determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 20-200 ng/ml. |
Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.
Interleukin-8 Porcine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 78 amino acids and having a molecular mass of 9.1kDa. The IL8 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. |
| UniProt Code: | P26894 |
| NCBI GenInfo Identifier: | 124360 |
| NCBI Gene ID: | 396880 |
| NCBI Accession: | P26894.1 |
| UniProt Secondary Accession: | P26894,P22951, |
| UniProt Related Accession: | P26894 |
| Molecular Weight: | 11,633 Da |
| NCBI Full Name: | Interleukin-8 |
| NCBI Official Symbol: | CXCL8�� |
| NCBI Official Synonym Symbols: | IL8; AMCF-I�� |
| NCBI Protein Information: | interleukin-8 |
| UniProt Protein Name: | Interleukin-8 |
| UniProt Synonym Protein Names: | Alveolar macrophage chemotactic factor I; AMCF-I; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | CXCL8�� |
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