Porcine IL-6 Recombinant Protein (His tag)
- SKU:
- RPES5820
- Product Type:
- Recombinant Protein
- Species:
- Porcine
Description
| Product Name: | Porcine IL-6 Recombinant Protein (His tag) |
| Product Code: | RPES5820 |
| Size: | 20µg |
| Species: | Porcine |
| Expression Host: | E.coli |
| Synonyms: | IFN-β2, B-Cell Differentiation Factor (BCDF), BSF-2, HPGF, HSF, MGI-2 |
| Mol Mass: | 20.13 kDa |
| AP Mol Mass: | 25 kDa |
| Tag: | N-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Pro 29-Met 212 |
| Accession: | P26893 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22-28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells. |
Related Products
Porcine S100A12 Recombinant Protein (His tag)
OverviewProduct Name:Porcine S100A12 Recombinant Protein (His tag)Product Code:RPES5824Size:20µgSpecies:Porcine
Porcine IGHE Recombinant Protein (His tag)
OverviewProduct Name:Porcine IGHE Recombinant Protein (His tag)Product Code:RPES6129Size:20µgSpecies:PorcineExp
Porcine IL-10 Recombinant Protein (GST tag)
OverviewProduct Name:Porcine IL-10 Recombinant Protein (GST tag)Product Code:RPES5821Size:20µgSpecies:PorcineE
Porcine OPN/Osteopontin Recombinant Protein (His tag)
OverviewProduct Name:Porcine OPN/Osteopontin Recombinant Protein (His tag)Product Code:RPES5822Size:20µgSpecies:Porcine
Porcine GFAP Recombinant Protein (His tag) (RPES5823)
Porcine GFAP Recombinant Protein (His tag) (RPES5823)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!