Porcine IL 2 Recombinant Protein (RPPB0484)
- SKU:
- RPPB0484
- Product Type:
- Recombinant Protein
- Species:
- Pig
- Uniprot:
- P26891
Description
| Product Name: | Porcine IL 2 Recombinant Protein |
| Product Code: | RPPB0484 |
| Size: | 10µg |
| Species: | Porcine |
| Target: | IL 2 |
| Synonyms: | T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized was lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized IL 2 in sterile distilled H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 96.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | APTSSSTKNT KKQLEPLLLD LQLLLKEVKN YENADLSRML TFKFYMPKQA TELKHLQCLV EELKALEGVL NLGQSKNSDS ANIKESMNNI NVTVLELKGS ETSFKCEYDD ETVTAVEFLN KWITFCQSIY STLT |
| Biological Activity: | The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5ng/ml, corresponding to a specific activity of > 2.0 � 106 IU/mg. |
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Interleukin2 Porcine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15217 Dalton. The IL-2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
| UniProt Code: | P26891 |
| NCBI GenInfo Identifier: | 47523136 |
| NCBI Gene ID: | 396868 |
| NCBI Accession: | NP_999026.1 |
| UniProt Related Accession: | P26891 |
| Molecular Weight: | |
| NCBI Full Name: | interleukin-2 |
| NCBI Official Symbol: | IL2�� |
| NCBI Official Synonym Symbols: | IL-2; TCGF; POIL2�� |
| NCBI Protein Information: | interleukin-2; T-cell growth factor |
| UniProt Protein Name: | Interleukin-2 |
| UniProt Synonym Protein Names: | T-cell growth factor; TCGF |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL2�� |
| UniProt Entry Name: | IL2_PIG |
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