POLR3H Antibody (PACO22315)
- SKU:
- PACO22315
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | POLR3H Antibody (PACO22315) |
| Antibody SKU: | PACO22315 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from internal of human RPC8. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from K562 cells, using RPC8 antibody. |
| Background: | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway By similarity. |
| Synonyms: | DNA-directed RNA polymerase III subunit RPC8; RNA polymerase III subunit C8; DNA-directed RNA polymerase III subunit H; DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide; POLR3H |
| UniProt Protein Function: | POLR3H: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 22q13.2Cellular Component: centrosome; cytosol; DNA-directed RNA polymerase III complex; intracellular membrane-bound organelle; nucleoplasmMolecular Function: DNA binding; DNA-directed RNA polymerase activityBiological Process: defense response to virus; gene expression; innate immune response; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; positive regulation of interferon type I production; RNA elongation from RNA polymerase III promoter; termination of RNA polymerase III transcription; transcription from RNA polymerase III promoter; transcription initiation from RNA polymerase III promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9Y535 |
| NCBI GenInfo Identifier: | 29428071 |
| NCBI Gene ID: | 171568 |
| NCBI Accession: | Q9Y535.1 |
| UniProt Secondary Accession: | Q9Y535,Q5M7Y8, Q96AE3, Q9BY95, B0QYH9 |
| UniProt Related Accession: | Q9Y535 |
| Molecular Weight: | 19,658 Da |
| NCBI Full Name: | DNA-directed RNA polymerase III subunit RPC8 |
| NCBI Synonym Full Names: | polymerase (RNA) III subunit H |
| NCBI Official Symbol: | POLR3H |
| NCBI Official Synonym Symbols: | RPC8; RPC22.9 |
| NCBI Protein Information: | DNA-directed RNA polymerase III subunit RPC8 |
| UniProt Protein Name: | DNA-directed RNA polymerase III subunit RPC8 |
| UniProt Synonym Protein Names: | DNA-directed RNA polymerase III subunit H; RNA polymerase III subunit 22.9 kDa subunit; RPC22.9 |
| Protein Family: | DNA-directed RNA polymerase |
| UniProt Gene Name: | POLR3H |
| UniProt Entry Name: | RPC8_HUMAN |
| Antibodies |
| POLR3H Antibody (PACO02585) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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