POLR3G Antibody (PACO02164)
- SKU:
- PACO02164
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | POLR3G Antibody |
| Antibody SKU: | PACO02164 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human POLR3G. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | POLR3G; DNA-directed RNA polymerase III subunit RPC7; RNA polymerase III subunit C7; DNA-directed RNA polymerase III subunit G; RNA polymerase III 32 kDa subunit; RPC32 |
| UniProt Protein Function: | POLR3G: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC7 RNA polymerase subunit family.Protein type: EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; TransferaseChromosomal Location of Human Ortholog: 5q14.3Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nuclear chromatin; nucleoplasmMolecular Function: DNA-directed RNA polymerase activityBiological Process: cell proliferation; positive regulation of innate immune response; positive regulation of interferon type I production; positive regulation of interferon-beta production; transcription initiation from RNA polymerase III promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O15318 |
| NCBI GenInfo Identifier: | 218511818 |
| NCBI Gene ID: | 10622 |
| NCBI Accession: | O15318.2 |
| UniProt Secondary Accession: | O15318,A8MTH0 |
| UniProt Related Accession: | O15318 |
| Molecular Weight: | 25,914 Da |
| NCBI Full Name: | DNA-directed RNA polymerase III subunit RPC7 |
| NCBI Synonym Full Names: | RNA polymerase III subunit G |
| NCBI Official Symbol: | POLR3G |
| NCBI Official Synonym Symbols: | RPC7; RPC32 |
| NCBI Protein Information: | DNA-directed RNA polymerase III subunit RPC7 |
| UniProt Protein Name: | DNA-directed RNA polymerase III subunit RPC7 |
| UniProt Synonym Protein Names: | DNA-directed RNA polymerase III subunit G; RNA polymerase III 32 kDa subunit; RPC32 |
| Protein Family: | |
| UniProt Gene Name: | POLR3G |
| UniProt Entry Name: | RPC7_HUMAN |
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