POLR2M Antibody (PACO54454)
- SKU:
- PACO54454
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | POLR2M Antibody (PACO54454) |
| Antibody SKU: | PACO54454 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 protein (2-91AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of A549 cells using PACO54454 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Synonyms: | DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (DNA-directed RNA polymerase II subunit M, isoforms 4/5), POLR2M, GRINL1A |
| UniProt Protein Function: | Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. |
| NCBI Summary: | This gene encodes a subunit of a specific form of RNA polymerase II termed Pol II(G). The encoded protein may act as a negative regulator of transcriptional activation by the Mediator complex. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 4. Readthrough transcription between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein) is represented with GeneID 145781. [provided by RefSeq, Oct 2013] |
| UniProt Code: | Q6EEV4 |
| NCBI GenInfo Identifier: | 70166832 |
| NCBI Gene ID: | 81488 |
| NCBI Accession: | NP_001018112.1 |
| UniProt Secondary Accession: | Q6EEV4,Q6EER8, Q6EES2, Q6EEV3, Q6EF00, Q6EF01, Q6EF02 Q6EF46, Q6EFN8, Q6EM48, Q6K046, Q6K050, |
| UniProt Related Accession: | P0CAP2,Q6EEV4 |
| Molecular Weight: | 15,131 Da |
| NCBI Full Name: | protein GRINL1A isoform 2 |
| NCBI Synonym Full Names: | RNA polymerase II subunit M |
| NCBI Official Symbol: | POLR2M |
| NCBI Official Synonym Symbols: | GCOM1; Gdown; Gdown1; GRINL1A |
| NCBI Protein Information: | protein GRINL1A |
| UniProt Protein Name: | DNA-directed RNA polymerase II subunit GRINL1A |
| UniProt Synonym Protein Names: | DNA-directed RNA polymerase II subunit M; Glutamate receptor-like protein 1A |
| Protein Family: | DNA-directed RNA polymerase |
| UniProt Gene Name: | POLR2M |
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