POLR1A Antibody (PACO11351)
- SKU:
- PACO11351
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | POLR1A Antibody (PACO11351) |
| Antibody SKU: | PACO11351 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human POLR1A |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | polymerase (RNA) I polypeptide A, 194kDa;POLR1A;DKFZp586M0122;FLJ21915;MGC87965;RPA1;RPO1-4 ;RPA194 |
| UniProt Protein Function: | POLR1A: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Belongs to the RNA polymerase beta' chain family.Protein type: Nucleolus; Transcription initiation complex; Nucleotide Metabolism - purine; Transferase; EC 2.7.7.6; Nucleotide Metabolism - pyrimidineChromosomal Location of Human Ortholog: 2p11.2Cellular Component: cytoplasm; DNA-directed RNA polymerase I complex; nucleolus; nucleoplasm; nucleusMolecular Function: protein bindingBiological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoterDisease: Acrofacial Dysostosis, Cincinnati Type |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016] |
| UniProt Code: | O95602 |
| NCBI GenInfo Identifier: | 215273873 |
| NCBI Gene ID: | 25885 |
| NCBI Accession: | O95602.2 |
| UniProt Secondary Accession: | O95602,Q0VG05, Q9UEH0, Q9UFT9, B7Z7T0, D6W5M0 |
| UniProt Related Accession: | O95602 |
| Molecular Weight: | 194,811 Da |
| NCBI Full Name: | DNA-directed RNA polymerase I subunit RPA1 |
| NCBI Synonym Full Names: | RNA polymerase I subunit A |
| NCBI Official Symbol: | POLR1A |
| NCBI Official Synonym Symbols: | A190; RPA1; RPO14; AFDCIN; RPA194; RPO1-4 |
| NCBI Protein Information: | DNA-directed RNA polymerase I subunit RPA1 |
| UniProt Protein Name: | DNA-directed RNA polymerase I subunit RPA1 |
| UniProt Synonym Protein Names: | A190; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RPA194 |
| Protein Family: | |
| UniProt Gene Name: | POLR1A |
| UniProt Entry Name: | RPA1_HUMAN |
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