Description
Antibody Name: | POLDIP3 Antibody (PACO55286) |
Antibody SKU: | PACO55286 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF, IP |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:20-1:200, IP:1:200-1:2000, |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Polymerase delta-interacting protein 3 protein (100-221AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, Jurkat whole cell lysate. All lanes: POLDIP3 antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47, 43 kDa. Observed band size: 43 kDa. | |
Immunofluorescence staining of Hela cells with PACO55286 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO55286 at dilution of 1:100. |
Background: | Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex. |
Synonyms: | Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR), POLDIP3, KIAA1649 PDIP46 |
UniProt Protein Function: | SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck Molecular Function:protein binding; nucleotide binding Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation |
NCBI Summary: | This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9BY77 |
NCBI GenInfo Identifier: | 50403796 |
NCBI Gene ID: | 84271 |
NCBI Accession: | Q9BY77.2 |
UniProt Secondary Accession: | Q9BY77,Q009A7, Q5H972, Q6PGN6, Q7Z6Z0, Q9NSP5, Q9NSP6 A8K6F8, A8K6V9, |
UniProt Related Accession: | Q9BY77 |
Molecular Weight: | 421 |
NCBI Full Name: | Polymerase delta-interacting protein 3 |
NCBI Synonym Full Names: | polymerase (DNA-directed), delta interacting protein 3 |
NCBI Official Symbol: | POLDIP3 |
NCBI Official Synonym Symbols: | SKAR; PDIP46 |
NCBI Protein Information: | polymerase delta-interacting protein 3; RNA-binding protein P46; S6K1 Aly/REF-like target; 46 kDa DNA polymerase delta interaction protein |
UniProt Protein Name: | Polymerase delta-interacting protein 3 |
UniProt Synonym Protein Names: | 46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target; SKAR |
Protein Family: | Polymerase delta-interacting protein |
UniProt Gene Name: | POLDIP3 |
UniProt Entry Name: | PDIP3_HUMAN |