PLXNC1 Antibody (PACO59848)
- SKU:
- PACO59848
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PLXNC1 Antibody (PACO59848) |
| Antibody SKU: | PACO59848 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Plexin-C1 protein (81-218AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO59848 at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). |
| Synonyms: | Plexin-C1 (Virus-encoded semaphorin protein receptor) (CD antigen CD232), PLXNC1, VESPR |
| UniProt Protein Function: | PLXNC1: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family.Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesionChromosomal Location of Human Ortholog: 12q23.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: protein binding; receptor binding; semaphorin receptor activityBiological Process: axon guidance; branchiomotor neuron axon guidance; cell adhesion; regulation of axon extension involved in axon guidance; regulation of cell migration |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | O60486 |
| NCBI GenInfo Identifier: | 74705745 |
| NCBI Gene ID: | 10154 |
| NCBI Accession: | O60486.1 |
| UniProt Secondary Accession: | O60486,Q59H25 |
| UniProt Related Accession: | O60486 |
| Molecular Weight: | 175,742 Da |
| NCBI Full Name: | Plexin-C1 |
| NCBI Synonym Full Names: | plexin C1 |
| NCBI Official Symbol: | PLXNC1 |
| NCBI Official Synonym Symbols: | CD232; VESPR; PLXN-C1 |
| NCBI Protein Information: | plexin-C1 |
| UniProt Protein Name: | Plexin-C1 |
| UniProt Synonym Protein Names: | Virus-encoded semaphorin protein receptor; CD_antigen: CD232 |
| Protein Family: | Plexin |
| UniProt Gene Name: | PLXNC1 |
| UniProt Entry Name: | PLXC1_HUMAN |
| Antibodies |
| PLXNC1 Antibody (PACO06911) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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