PLPP2 Antibody (PACO29100)
- SKU:
- PACO29100
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PLPP2 Antibody (PACO29100) |
| Antibody SKU: | PACO29100 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phospholipid phosphatase 2 protein (109-162AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: PLPP2 antibody at 8µg/ml + MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 33, 35, 27 kDa Observed band size: 33 kDa . |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO29100 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO29100 at dilution of 1:100. |
| Background: | Catalyzes the conversion of phosphatidic acid, (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid, (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. |
| Synonyms: | Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid, phosphatase 2c) (PAP-2c) (PAP2c), PLPP2, LPP2 PPAP2C |
| UniProt Protein Function: | PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Membrane protein, multi-pass; EC 3.1.3.4; Lipid Metabolism - glycerolipid; Phosphatase, lipid; Membrane protein, integral; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - sphingolipidChromosomal Location of Human Ortholog: 19p13Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: lipid phosphatase activity; phosphoprotein phosphatase activity; protein binding; sphingosine-1-phosphate phosphatase activityBiological Process: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction; sphingolipid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43688 |
| NCBI GenInfo Identifier: | 45504419 |
| NCBI Gene ID: | 8612 |
| NCBI Accession: | O43688.1 |
| UniProt Secondary Accession: | O43688,A6NLV0, E9PAY8 |
| UniProt Related Accession: | O43688 |
| Molecular Weight: | 26,103 Da |
| NCBI Full Name: | Phospholipid phosphatase 2 |
| NCBI Synonym Full Names: | phospholipid phosphatase 2 |
| NCBI Official Symbol: | PLPP2 |
| NCBI Official Synonym Symbols: | LPP2; PAP-2c; PAP2-g; PPAP2C |
| NCBI Protein Information: | phospholipid phosphatase 2 |
| UniProt Protein Name: | Phospholipid phosphatase 2 |
| UniProt Synonym Protein Names: | Lipid phosphate phosphohydrolase 2; PAP2-gamma; PAP2-G; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c; PAP-2c; PAP2c |
| Protein Family: | |
| UniProt Gene Name: | PLPP2 |
| UniProt Entry Name: | PLPP2_HUMAN |
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