PLK1 Monoclonal Antibody (CAB22595)
- SKU:
- CAB22595
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | PLK1 Monoclonal Antibody |
| Product Code: | CAB22595 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52313 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, K-562, Mouse testis, Rat testis |
| Cellular Location: | Chromosome, Cytoplasm, Midbody, Nucleus, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center, spindle |
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 272-495 of human PLK1 (NP_005021.2). |
| Sequence: | KHINP VAASL IQKML QTDPT ARPTI NELLN DEFFT SGYIP ARLPI TCLTI PPRFS IAPSS LDPSN RKPLT VLNKG LENPL PERPR EKEEP VVRET GEVVD CHLSD MLQQL HSVNA SKPSE RGLVR QEEAE DPACI PIFWV SKWVD YSDKY GLGYQ LCDNS VGVLF NDSTR LILYN DGDSL QYIER DGTES YLTVS SHPNS LMKKI TLLKY FRNYM SEHLL KAGA |
| Synonyms: | PLK, STPK13 |
| Calculated MW: | 68kDa |
| Observed MW: | Refer to figures |
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