Name: PLEKHO1 Antibody (PACO17709)
SKU: PACO17709
Availability: OutOfStock

Antibody Name:	PLEKHO1 Antibody (PACO17709)
Antibody SKU:	PACO17709
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human PLEKHO1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO17709(PLEKHO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.PLEKHO1 has been shown to interact with Casein kinase 2, α 1 and SMURF1.It plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Appears to target ATM to the plasma membrane,and also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. The protein implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Synonyms:

pleckstrin homology domain containing, family O member 1

UniProt Protein Function:	PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Adaptor/scaffold; Tumor suppressor Chromosomal Location of Human Ortholog: 1q21.2 Molecular Function:protein binding
UniProt Code:	Q53GL0
NCBI GenInfo Identifier:	160419242
NCBI Gene ID:	51177
NCBI Accession:	Q53GL0.2
UniProt Secondary Accession:	Q53GL0,Q336K5, Q8IZ51, Q9NRV3, Q9UL48,
UniProt Related Accession:	Q53GL0
Molecular Weight:	42,330 Da
NCBI Full Name:	Pleckstrin homology domain-containing family O member 1
NCBI Synonym Full Names:	pleckstrin homology domain containing O1
NCBI Official Symbol:	PLEKHO1
NCBI Official Synonym Symbols:	JBP; CKIP1; OC120; CKIP-1
NCBI Protein Information:	pleckstrin homology domain-containing family O member 1
UniProt Protein Name:	Pleckstrin homology domain-containing family O member 1
UniProt Synonym Protein Names:	C-Jun-binding protein; JBP; Casein kinase 2-interacting protein 1; CK2-interacting protein 1; CKIP-1; Osteoclast maturation-associated gene 120 protein
Protein Family:	Pleckstrin homology domain-containing family
UniProt Gene Name:	PLEKHO1
UniProt Entry Name:	PKHO1_HUMAN