Pleiotrophin/PTN/HB-GAM Recombinant Protein (RPES0888)

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SKU:
RPES0888
Product Type:
Recombinant Protein
Species:
Mouse

Description

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Pleiotrophin/PTN/HB-GAM Recombinant Protein

Pleiotrophin (PTN) is an secreted, strongly heparinbinding,developmentally regulated cytokine. PTN and midkine share50% amino acid (aa) sequence identity, share some functions, and constitute a family. PTN is a highly conserved protein? human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity orgreater. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates its phosphatase activity, which allows increased tyrosine phosphorylation of its substrates. Increased expression of PTN is correlated withneuronal development or stresses such as brain ischemia and Parkinson’s disease.

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