Plectin Monoclonal Antibody
- SKU:
- CAB23479
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | Plectin Monoclonal Antibody |
| Product Code: | CAB23479 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53240 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:100-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | cytoplasm, cytosol, extracellular exosome, focal adhesion, intermediate filament cytoskeleton, mitochondrial outer membrane, perinuclear region of cytoplasm, plasma membrane, Z disc |
Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .
| Immunogen: | Recombinant protein of human Plectin . |
| Sequence: | Email for sequence |
| Synonyms: | HD1, PCN, EBS1, EBSO, PLTN, EBS5A, EBS5B, EBS5C, EBS5D, EBSMD, EBSND, EBSOG, EBSPA, PLEC1, LGMD2Q, PLEC1b, LGMDR17 |
| Calculated MW: | 532kDa |
| Observed MW: | Refer to figures |
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