Description
Antibody Name: | PLCD1 Antibody (PACO49878) |
Antibody SKU: | PACO49878 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 protein (419-653AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO49878 at dilution of 1:100. |
Background: | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. |
Synonyms: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1), PLCD1 |
UniProt Protein Function: | PLCD1: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Defects in PLCD1 are the cause of nail disorder non- syndromic congenital type 3 (NDNC3). NDNC3 is a nail disorder characterized by a white appearance of the nail plate (true leukonychia), the nail bed (pseudoleukonychia), or neither (apparent leukonychia). Leukonychia may involve all of the nail (leukonychia totalis) or only part of the nail (leukonychia partialis), or can appear as one or more transverse bands (leukonychia striata) or white spots (leukonychia punctata). 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; PhospholipaseChromosomal Location of Human Ortholog: 3p22-p21.3Cellular Component: cytoplasm; plasma membrane; cytosolMolecular Function: signal transducer activity; phosphatidylserine binding; GTPase activating protein binding; calcium ion binding; phosphoinositide phospholipase C activityBiological Process: inositol phosphate metabolic process; phospholipid metabolic process; angiogenesis; lipid catabolic process; regulation of cell proliferationDisease: Nail Disorder, Nonsyndromic Congenital, 3 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | P51178 |
NCBI GenInfo Identifier: | 206729887 |
NCBI Gene ID: | 5333 |
NCBI Accession: | P51178.2 |
UniProt Secondary Accession: | P51178,Q86VN8, B3KR14 |
UniProt Related Accession: | P51178 |
Molecular Weight: | 88,135 Da |
NCBI Full Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
NCBI Synonym Full Names: | phospholipase C, delta 1 |
NCBI Official Symbol: | PLCD1 |
NCBI Official Synonym Symbols: | NDNC3; PLC-III |
NCBI Protein Information: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; PLC-delta-1; phospholipase C-III; phosphoinositide phospholipase C-delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1 |
UniProt Protein Name: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
UniProt Synonym Protein Names: | Phosphoinositide phospholipase C-delta-1; Phospholipase C-III; PLC-III; Phospholipase C-delta-1; PLC-delta-1 |
Protein Family: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase |
UniProt Gene Name: | PLCD1 |
UniProt Entry Name: | PLCD1_HUMAN |
Antibodies |
PLCD1 Antibody (PACO11287) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |