PLC gamma 1 (PLCG1) Polyclonal Antibody

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SKU:
CAB21545
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:PLC gamma 1 (PLCG1) Polyclonal Antibody
Product Code:CAB21545
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location:Cell projection, lamellipodium, ruffle

The protein encoded by this gene catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1202-1291 of human PLC gamma 1 (PLCG1) (NP_002651.2).
Sequence:LASLL IKIDI FPAKQ ENGDL SPFSG TSLRE RGSDA SGQLF HGRAR EGSFE SRYQQ PFEDF RISQE HLADH FDSRE RRAPR RTRVN GDNRL
Synonyms:PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1
Calculated MW:149kDa
Observed MW:Refer to figures
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