Plaur Antibody (PACO28986)
- SKU:
- PACO28986
- Product Type:
- Antibody
- Reactivity:
- Rat
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Plaur Antibody (PACO28986) |
| Antibody SKU: | PACO28986 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Urokinase plasminogen activator surface receptor ptotein (25-299AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Plaur antibody at 2µg/ml Lane 1: 293T whole cell lysate Lane 2: Rat brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36, 25 kDa Observed band size: 36 kDa . |
| Background: | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. |
| Synonyms: | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (CD_antigen: CD87), Plaur |
| UniProt Protein Function: | uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cell surface; extracellular region; focal adhesion; integral component of plasma membrane; plasma membrane Molecular Function:enzyme binding; protein domain specific binding; receptor binding; U-plasminogen activator receptor activity Biological Process: mesenchymal cell differentiation; negative regulation of apoptosis; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein phosphorylation; regulation of proteolysis; skeletal muscle tissue regeneration; spermatogenesis |
| NCBI Summary: | receptor for urokinase-plasminogen activator; may play a central role in malignant tumour progression [RGD, Feb 2006] |
| UniProt Code: | P49616 |
| NCBI GenInfo Identifier: | 8394516 |
| NCBI Gene ID: | 50692 |
| NCBI Accession: | NP_059046.1 |
| UniProt Secondary Accession: | P49616,O35771, P51573, Q7TN35, |
| UniProt Related Accession: | P49616 |
| Molecular Weight: | 24,417 Da |
| NCBI Full Name: | urokinase plasminogen activator surface receptor isoform 2 |
| NCBI Synonym Full Names: | plasminogen activator, urokinase receptor |
| NCBI Official Symbol: | Plaur |
| NCBI Official Synonym Symbols: | Par; uPAR; Plaur3; uPAR-2; uPAR-3 |
| NCBI Protein Information: | urokinase plasminogen activator surface receptor |
| UniProt Protein Name: | Urokinase plasminogen activator surface receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD87 |
| UniProt Gene Name: | Plaur |
| ELISA Kits |
| Rat uPAR ELISA Kit |
| Rat PLAUR/uPAR (Plasminogen Activator, Urokinase Receptor) CLIA Kit (RTES00586) |
| Rat Urokinase plasminogen activator surface receptor (Plaur) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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