Placental alkaline phosphatase (PLAP) Polyclonal Antibody
- SKU:
- CAB21424
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IP
Description
| Product Name: | Placental alkaline phosphatase (PLAP) Polyclonal Antibody |
| Product Code: | CAB21424 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IP, ELISA |
| Key Applications: | Western blotting, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:2000, IP 50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-460 of human Placental alkaline phosphatase (PLAP) (NP_001623.3). |
| Sequence: | LAKRQ GARYV WNRTE LMQAS LDPSV THLMG LFEPG DMKYE IHRDS TLDPS LMEMT EAALR LLSRN PRGFF LFVEG GRIDH GHHES RAYRA LTETI MFDDA IERAG QLTSE EDTLS LVTAD HSHVF SFGGY PLRGS SIFGL APGKA RDRKA YTVLL YGNGP GYVLK DGARP DVTES ESGSP EYRQQ SAVPL DEETH AGEDV A |
| Synonyms: | ALP, IAP, ALPI, PALP, PLAP, PLAP-1 |
| Calculated MW: | 58kDa |
| Observed MW: | Refer to figures |
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