Pla2g5 Antibody (PACO28978)
- SKU:
- PACO28978
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Pla2g5 Antibody (PACO28978) |
| Antibody SKU: | PACO28978 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Calcium-dependent phospholipase A2 protein (21-137AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L-alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol (By similarity). |
| Synonyms: | Calcium-dependent phospholipase A2 (EC 3.1.1.4) (Group V phospholipase A2) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5), Pla2g5 |
| UniProt Protein Function: | PLA2G5: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. Defects in PLA2G5 are the cause of fleck retina, familial benign (FRFB). An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. Belongs to the phospholipase A2 family.Protein type: Cell surface; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 4 D3|4 70.57 cMCellular Component: cell surface; Golgi apparatus; perinuclear region of cytoplasm; plasma membraneMolecular Function: calcium-dependent phospholipase A2 activity; heparin binding; phospholipase A2 activity; receptor bindingBiological Process: arachidonic acid secretion; leukotriene biosynthetic process; negative regulation of inflammatory response; phospholipid metabolic process; platelet activating factor biosynthetic process; regulation of macrophage activation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P97391 |
| NCBI GenInfo Identifier: | 171906563 |
| NCBI Gene ID: | 18784 |
| NCBI Accession: | NP_001116426.1 |
| UniProt Secondary Accession: | P97391,Q9QZU6 |
| UniProt Related Accession: | P97391 |
| Molecular Weight: | 29.8kD |
| NCBI Full Name: | calcium-dependent phospholipase A2 |
| NCBI Synonym Full Names: | phospholipase A2, group V |
| NCBI Official Symbol: | Pla2g5 |
| NCBI Official Synonym Symbols: | PLA2; sPLA2 |
| NCBI Protein Information: | calcium-dependent phospholipase A2 |
| UniProt Protein Name: | Calcium-dependent phospholipase A2 |
| UniProt Synonym Protein Names: | Group V phospholipase A2; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5 |
| Protein Family: | Calcium-dependent phospholipase |
| UniProt Gene Name: | Pla2g5 |
| UniProt Entry Name: |
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