Name: PLA2G4E Antibody (PACO22299)
SKU: PACO22299
Availability: OutOfStock

Antibody Name:	PLA2G4E Antibody (PACO22299)
Antibody SKU:	PACO22299
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human PLA2G4E.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PLA2G4E antibody.

Background:	Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position By similarity.
Synonyms:	Cytosolic phospholipase A2 epsilon; EC 3.1.1.4; cPLA2-epsilon; Phospholipase A2 group IVE;

UniProt Protein Function:	PLA2G4E: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Translocates to lysosomal membranes in a calcium-dependent fashion. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4Chromosomal Location of Human Ortholog: 15q15.1Cellular Component: lysosomal membrane; cytosolMolecular Function: phospholipase A2 activity; metal ion bindingBiological Process: phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q3MJ16
NCBI GenInfo Identifier:	331284217
NCBI Gene ID:	123745
NCBI Accession:	NP_001193599.1
UniProt Secondary Accession:	Q3MJ16,Q6ZSC0
UniProt Related Accession:	Q3MJ16
Molecular Weight:	56,715 Da
NCBI Full Name:	cytosolic phospholipase A2 epsilon
NCBI Synonym Full Names:	phospholipase A2, group IVE
NCBI Official Symbol:	PLA2G4E
NCBI Official Synonym Symbols:
NCBI Protein Information:	cytosolic phospholipase A2 epsilon; cPLA2-epsilon
UniProt Protein Name:	Cytosolic phospholipase A2 epsilon
UniProt Synonym Protein Names:	Phospholipase A2 group IVE
Protein Family:	Cytosolic phospholipase
UniProt Gene Name:	PLA2G4E
UniProt Entry Name:	PA24E_HUMAN