| UniProt Protein Function: | PLA2G4E: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Translocates to lysosomal membranes in a calcium-dependent fashion. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4Chromosomal Location of Human Ortholog: 15q15.1Cellular Component: lysosomal membrane; cytosolMolecular Function: phospholipase A2 activity; metal ion bindingBiological Process: phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q3MJ16 |
| NCBI GenInfo Identifier: | 331284217 |
| NCBI Gene ID: | 123745 |
| NCBI Accession: | NP_001193599.1 |
| UniProt Secondary Accession: | Q3MJ16,Q6ZSC0 |
| UniProt Related Accession: | Q3MJ16 |
| Molecular Weight: | 56,715 Da |
| NCBI Full Name: | cytosolic phospholipase A2 epsilon |
| NCBI Synonym Full Names: | phospholipase A2, group IVE |
| NCBI Official Symbol: | PLA2G4E |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cytosolic phospholipase A2 epsilon; cPLA2-epsilon |
| UniProt Protein Name: | Cytosolic phospholipase A2 epsilon |
| UniProt Synonym Protein Names: | Phospholipase A2 group IVE |
| Protein Family: | Cytosolic phospholipase |
| UniProt Gene Name: | PLA2G4E |
| UniProt Entry Name: | PA24E_HUMAN |
