PLA2G4B Antibody (PACO19501)
- SKU:
- PACO19501
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PLA2G4B Antibody (PACO19501) |
| Antibody SKU: | PACO19501 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human PLA2G4B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse stomach tissue, 293T cells, Jurkat cells, Primary antibody: PACO19501(PLA2G4B Antibody) at dilution 1/1400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acid, . This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. |
| Synonyms: | phospholipase A2, group IVB (cytosolic) |
| UniProt Protein Function: | PLA2G4B: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Not inhibited by pyrrolidine-2 and Wyeth-1. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Four isoforms of the human protein are produced by alternative splicing. Isoform 3 translocates to membrane vesicles in a calcium-dependent fashion and has activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine.Protein type: Phospholipase; EC 3.1.1.4; Lipid Metabolism - arachidonic acidChromosomal Location of Human Ortholog: 15q11.2-q21.3Cellular Component: cytosol; extracellular region; mitochondrial inner membraneMolecular Function: calcium-dependent phospholipase A2 activity; lysophospholipase activity; phospholipase A1 activity; phospholipase A2 activityBiological Process: glycerophospholipid catabolic process; phosphatidic acid biosynthetic process; phospholipid metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P0C869 |
| NCBI GenInfo Identifier: | 300669659 |
| NCBI Gene ID: | 100137049 |
| NCBI Accession: | P0C869.2 |
| UniProt Secondary Accession: | P0C869,O95712, Q19KD5, Q19KD6, Q59GF9, Q8TB10, Q9UKV7 B4DRT9 |
| UniProt Related Accession: | P0C869 |
| Molecular Weight: | 114,121 Da |
| NCBI Full Name: | Cytosolic phospholipase A2 beta |
| NCBI Synonym Full Names: | phospholipase A2 group IVB |
| NCBI Official Symbol: | PLA2G4B |
| NCBI Official Synonym Symbols: | HsT16992; cPLA2-beta |
| NCBI Protein Information: | cytosolic phospholipase A2 beta |
| UniProt Protein Name: | Cytosolic phospholipase A2 beta |
| UniProt Synonym Protein Names: | Phospholipase A2 group IVB |
| Protein Family: | Cytosolic phospholipase |
| UniProt Gene Name: | PLA2G4B |
| UniProt Entry Name: | PA24B_HUMAN |
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