Description
Antibody Name: | Pla2g2a Antibody (PACO34222) |
Antibody SKU: | PACO34222 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA |
Recommended Dilutions: | |
Species Reactivity: | Rat |
Immunogen: | Recombinant Rat Phospholipase A2, membrane associated protein (22-146AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Background: | Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
Synonyms: | Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A), Pla2g2a |
UniProt Protein Function: | Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
UniProt Protein Details: | Catalytic activity: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. Cofactor: Binds 1 calcium ion per subunit By similarity. Subcellular location: Membrane; Peripheral membrane protein. Miscellaneous: Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene. Sequence similarities: Belongs to the phospholipase A2 family. |
NCBI Summary: | hydrolyzes acyl group at the sn-2 position of phospholipids, forming non-esterified fatty acids and lysophospholipids; plays a critical role in inflammation; induces proliferation of smooth muscle cells [RGD, Feb 2006] |
UniProt Code: | P14423 |
NCBI GenInfo Identifier: | 291621686 |
NCBI Gene ID: | 29692 |
NCBI Accession: | NP_113786.3 |
UniProt Related Accession: | P14423 |
Molecular Weight: | 16,294 Da |
NCBI Full Name: | phospholipase A2, membrane associated |
NCBI Synonym Full Names: | phospholipase A2, group IIA (platelets, synovial fluid) |
NCBI Official Symbol: | Pla2g2a |
NCBI Official Synonym Symbols: | sPLA2 |
NCBI Protein Information: | phospholipase A2, membrane associated; GIIC sPLA2; platelet phospholipase A2; group IIA phospholipase A2; eted enzyme type IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A |
UniProt Protein Name: | Phospholipase A2, membrane associated |
UniProt Synonym Protein Names: | GIIC sPLA2; Group IIA phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2A |
Protein Family: | Phospholipase |
UniProt Gene Name: | Pla2g2a |
UniProt Entry Name: | PA2GA_RAT |