PLA1A Antibody (PACO02962)
- SKU:
- PACO02962
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PLA1A Antibody |
| Antibody SKU: | PACO02962 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the C-terminal region of human PLA1A. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PLA1A; NMD; PSPLA1; Phospholipase A1 member A; Phosphatidylserine-specific phospholipase A1; PS-PLA1 |
| UniProt Protein Function: | PLA1A: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. Belongs to the AB hydrolase superfamily. Lipase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.1.1.-; Secreted; Phospholipase Chromosomal Location of Human Ortholog: 3q13.13-q13.2 Cellular Component: acrosomal membrane Molecular Function:phospholipase A1 activity Biological Process: lipid catabolic process; lipid metabolic process; phosphatidylserine metabolic process |
| NCBI Summary: | The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] |
| UniProt Code: | Q53H76 |
| NCBI GenInfo Identifier: | 124015212 |
| NCBI Gene ID: | 51365 |
| NCBI Accession: | Q53H76.2 |
| UniProt Secondary Accession: | Q53H76,O95991, Q86WX6, Q9UPD2, B2R8V2, B4DXA2, |
| UniProt Related Accession: | Q53H76 |
| Molecular Weight: | 31,285 Da |
| NCBI Full Name: | Phospholipase A1 member A |
| NCBI Synonym Full Names: | phospholipase A1 member A |
| NCBI Official Symbol: | PLA1A |
| NCBI Official Synonym Symbols: | PSPLA1; PS-PLA1 |
| NCBI Protein Information: | phospholipase A1 member A |
| UniProt Protein Name: | Phospholipase A1 member A |
| UniProt Synonym Protein Names: | Phosphatidylserine-specific phospholipase A1; PS-PLA1 |
| Protein Family: | Phospholipase |
| UniProt Gene Name: | PLA1A |
| UniProt Entry Name: | PLA1A_HUMAN |
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