PKM2-specific Monoclonal Antibody (CAB22408)
- SKU:
- CAB22408
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PKM2-specific Monoclonal Antibody |
| Product Code: | CAB22408 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC50917 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, HepG2, NIH/3T3, C6, Mouse skeletal muscle(negative), Mouse heart(negative), Rat skeletal muscle(negative), Rat heart(negative) |
| Cellular Location: | Cytoplasm, Nucleus |
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 380-480 of human PKM2-specific (NP_002645.3). |
| Sequence: | LIARE AEAAI YHLQL FEELR RLAPI TSDPT EATAV GAVEA SFKCC SGAII VLTKS GRSAH QVARY RPRAP IIAVT RNPQT ARQAH LYRGI FPVLC KDPVQ E |
| Synonyms: | PK3, TCB, p58, OIP3, PKM2, CTHBP, THBP1, HEL-S-30 |
| Calculated MW: | 58kDa |
| Observed MW: | 60kDa |
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