PKIG Antibody (PACO59972)
- SKU:
- PACO59972
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PKIG Antibody (PACO59972) |
| Antibody SKU: | PACO59972 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human cAMP-dependent protein kinase inhibitor γ protein (1-76AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of PC-3 cells with PACO59972 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. |
| Synonyms: | cAMP-dependent protein kinase inhibitor γ (PKI-gamma), PKIG |
| UniProt Protein Function: | PKIG: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family. |
| UniProt Protein Details: | Protein type:Inhibitor; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 20q12-q13.1 Cellular Component: cytoplasm; nucleus Molecular Function:cAMP-dependent protein kinase inhibitor activity Biological Process: negative regulation of protein import into nucleus; negative regulation of transcription from RNA polymerase II promoter; signal transduction |
| NCBI Summary: | This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9Y2B9 |
| NCBI GenInfo Identifier: | 74355324 |
| NCBI Gene ID: | 11142 |
| NCBI Accession: | AAI04257.1 |
| UniProt Related Accession: | Q9Y2B9 |
| Molecular Weight: | 7,910 Da |
| NCBI Full Name: | Protein kinase (cAMP-dependent, catalytic) inhibitor gamma |
| NCBI Synonym Full Names: | protein kinase (cAMP-dependent, catalytic) inhibitor gamma |
| NCBI Official Symbol: | PKIG |
| NCBI Official Synonym Symbols: | PKI-gamma |
| NCBI Protein Information: | cAMP-dependent protein kinase inhibitor gamma |
| UniProt Protein Name: | cAMP-dependent protein kinase inhibitor gamma |
| Protein Family: | cAMP-dependent protein kinase |
| UniProt Gene Name: | PKIG |
| UniProt Entry Name: | IPKG_HUMAN |
| Antibodies | ELISA Kits |
| PKIG Antibody (PACO11270) | Human PKIgamma (Protein Kinase Inhibitor Gamma) ELISA Kit (HUES02267) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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