PKD1L1 Antibody (PACO53138)
- SKU:
- PACO53138
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PKD1L1 Antibody (PACO53138) |
| Antibody SKU: | PACO53138 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Polycystic kidney disease protein 1-like 1 protein (921-1164AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO53138 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO53138 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. |
| Synonyms: | Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1), PKD1L1 |
| UniProt Protein Function: | Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TDX9 |
| NCBI GenInfo Identifier: | 19923084 |
| NCBI Gene ID: | 168507 |
| NCBI Accession: | NP_612152.1 |
| UniProt Secondary Accession: | Q8TDX9,Q6UWK1 |
| UniProt Related Accession: | Q8TDX9 |
| Molecular Weight: | |
| NCBI Full Name: | polycystic kidney disease protein 1-like 1 |
| NCBI Synonym Full Names: | polycystin 1 like 1, transient receptor potential channel interacting |
| NCBI Official Symbol: | PKD1L1 |
| NCBI Official Synonym Symbols: | HTX8; PRO19563 |
| NCBI Protein Information: | polycystic kidney disease protein 1-like 1 |
| UniProt Protein Name: | Polycystic kidney disease protein 1-like 1 |
| UniProt Synonym Protein Names: | PC1-like 1 protein; Polycystin-1L1 |
| Protein Family: | Polycystic kidney disease |
| UniProt Gene Name: | PKD1L1 |
| UniProt Entry Name: |
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