PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)
![PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58355/63537/pin1-monoclonal-antibody-p3g8at-cpab0129__12632__68785.1706534982.jpg?c=1 "PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)")
- SKU:
- CPAB0129
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- P3G8AT
- Applications:
- WB
- Applications:
- ELISA
![PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58355/63537/pin1-monoclonal-antibody-p3g8at-cpab0129__12632__68785.1706534982.jpg?c=1&imbypass=on "PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)")
Description
system_update_alt Datasheet
| Product Name: | PIN1 Antibody |
| Product Sku: | CPAB0129 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PIN1 mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PIN1 amino acids 1-163 purified from Ecoli. |
| Clone: | P3G8AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | |
| Isotype: | IgG1 |
| Background: | Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like β-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1. |
| Synonyms: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, EC 5.2.1.8, Rotamase Pin1, PPIase Pin1, DOD, UBL5, PIN1, PPIase. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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