Name: PILRB Antibody (PACO16869)
SKU: PACO16869
Availability: OutOfStock

Antibody Name:	PILRB Antibody (PACO16869)
Antibody SKU:	PACO16869
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, IHC:1:20-1:100
Species Reactivity:	Human
Immunogen:	Fusion protein of human PILRB

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16869(PILRB Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).

Background:

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs.

Synonyms:

paired immunoglobin-like type 2 receptor beta

UniProt Protein Function:	PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Immunoglobulin superfamily Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to plasma membrane Molecular Function:protein binding Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway
NCBI Summary:	The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
UniProt Code:	Q9UKJ0
NCBI GenInfo Identifier:	74761987
NCBI Gene ID:	29990
NCBI Accession:	Q9UKJ0.1
UniProt Secondary Accession:	Q9UKJ0,Q69YF9, Q9HBS0,
UniProt Related Accession:	Q9UKJ0
Molecular Weight:	29,630 Da
NCBI Full Name:	Paired immunoglobulin-like type 2 receptor beta
NCBI Synonym Full Names:	paired immunoglobin-like type 2 receptor beta
NCBI Official Symbol:	PILRB
NCBI Official Synonym Symbols:	FDFACT1; FDFACT2
NCBI Protein Information:	paired immunoglobulin-like type 2 receptor beta; activating receptor PILR-beta; activating receptor PILRbeta; cell surface receptor FDFACT; cell surface receptor FDFACT1; cell surface receptor FDFACT2; paired immunoglobin-like receptor beta; paired immunoglobulin-like receptor beta
UniProt Protein Name:	Paired immunoglobulin-like type 2 receptor beta
UniProt Synonym Protein Names:	Activating receptor PILR-beta; Cell surface receptor FDFACT
Protein Family:	Paired immunoglobulin-like type 2 receptor
UniProt Gene Name:	PILRB
UniProt Entry Name:	PILRB_HUMAN