PIK3AP1 Antibody (PACO57232)
- SKU:
- PACO57232
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PIK3AP1 Antibody (PACO57232) |
| Antibody SKU: | PACO57232 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phosphoinositide 3-kinase adapter protein 1 protein (293-404AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO57232 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. |
| Synonyms: | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1), PIK3AP1, BCAP |
| UniProt Protein Function: | BCAP: an adaptor protein for phosphoinositide-3-kinase. Plays a role in connecting B-cell antigen receptor signaling to phosphoinositide 3-kinase activation.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 10q24.1Cellular Component: cytosol; membrane; plasma membraneBiological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of inflammatory response; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6ZUJ8 |
| NCBI GenInfo Identifier: | 205830907 |
| NCBI Gene ID: | 118788 |
| NCBI Accession: | Q6ZUJ8.2 |
| UniProt Secondary Accession: | Q6ZUJ8,Q5TB56, Q5VXJ9, Q8N6J6, Q8NAC8 |
| UniProt Related Accession: | Q6ZUJ8 |
| Molecular Weight: | 45,484 Da |
| NCBI Full Name: | Phosphoinositide 3-kinase adapter protein 1 |
| NCBI Synonym Full Names: | phosphoinositide-3-kinase adaptor protein 1 |
| NCBI Official Symbol: | PIK3AP1 |
| NCBI Official Synonym Symbols: | BCAP |
| NCBI Protein Information: | phosphoinositide 3-kinase adapter protein 1 |
| UniProt Protein Name: | Phosphoinositide 3-kinase adapter protein 1 |
| UniProt Synonym Protein Names: | B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1 |
| Protein Family: | Phosphoinositide 3-kinase adapter protein |
| UniProt Gene Name: | PIK3AP1 |
| UniProt Entry Name: | BCAP_HUMAN |
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