PIF1 Antibody (PACO47030)
- SKU:
- PACO47030
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PIF1 Antibody (PACO47030) |
| Antibody SKU: | PACO47030 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human ATP-dependent DNA helicase PIF1 protein (125-360AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO47030 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO47030 at dilution of 1:100. |
| Background: | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. |
| Synonyms: | ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) (PIF1/RRM3 DNA helicase-like protein), PIF1, C15orf20 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013] |
| UniProt Code: | Q9H611 |
| NCBI GenInfo Identifier: | 152031656 |
| NCBI Gene ID: | 80119 |
| NCBI Accession: | Q9H611.2 |
| UniProt Secondary Accession: | Q9H611 |
| UniProt Related Accession: | Q9H611 |
| Molecular Weight: | |
| NCBI Full Name: | ATP-dependent DNA helicase PIF1 |
| NCBI Synonym Full Names: | PIF1 5'-to-3' DNA helicase |
| NCBI Official Symbol: | PIF1 |
| NCBI Official Synonym Symbols: | PIF; C15orf20 |
| NCBI Protein Information: | ATP-dependent DNA helicase PIF1 |
| UniProt Protein Name: | ATP-dependent DNA helicase PIF1 |
| UniProt Synonym Protein Names: | DNA repair and recombination helicase PIF1 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | PIF1 |
| UniProt Entry Name: | PIF1_HUMAN |
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