PIF1 Antibody (PACO18213)
- SKU:
- PACO18213
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PIF1 Antibody (PACO18213) |
| Antibody SKU: | PACO18213 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human PIF1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, Hela cells, Primary antibody: PACO18213(PIF1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT; MIM 187270), a reverse transcriptase that maintains telomere length. Tightly cell cycle regulated and expressed in late S/G2 phase. |
| Synonyms: | ATP-dependent DNA helicase PIF1 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a DNA-dependent adenosine triphosphate (ATP)-metabolizing enzyme that functions as a 5' to 3' DNA helicase. The encoded protein can resolve G-quadruplex structures and RNA-DNA hybrids at the ends of chromosomes. It also prevents telomere elongation by inhibiting the actions of telomerase. Alternative splicing and the use of alternative start codons results in multiple isoforms that are differentially localized to either the mitochondria or the nucleus. [provided by RefSeq, Nov 2013] |
| UniProt Code: | Q9H611 |
| NCBI GenInfo Identifier: | 152031656 |
| NCBI Gene ID: | 80119 |
| NCBI Accession: | Q9H611.2 |
| UniProt Secondary Accession: | Q9H611 |
| UniProt Related Accession: | Q9H611 |
| Molecular Weight: | |
| NCBI Full Name: | ATP-dependent DNA helicase PIF1 |
| NCBI Synonym Full Names: | PIF1 5'-to-3' DNA helicase |
| NCBI Official Symbol: | PIF1 |
| NCBI Official Synonym Symbols: | PIF; C15orf20 |
| NCBI Protein Information: | ATP-dependent DNA helicase PIF1 |
| UniProt Protein Name: | ATP-dependent DNA helicase PIF1 |
| UniProt Synonym Protein Names: | DNA repair and recombination helicase PIF1 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | PIF1 |
| UniProt Entry Name: | PIF1_HUMAN |
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