Phospho-ZAP70-Y493 Monoclonal Antibody
- SKU:
- CABP1435
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | Phospho-ZAP70-Y493 Monoclonal Antibody |
| Product Code: | CABP1435 |
| Reactivity: | Human |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59392 |
| Reactivity: | Human |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, Peripheral membrane protein |
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
| Immunogen: | A synthetic phosphorylated peptide around Y493 of human ZAP70. |
| Sequence: | SYYTA |
| Synonyms: | ZAP70, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70, tyrosine-protein kinase ZAP-70 |
| Calculated MW: | 70kDa |
| Observed MW: | Refer to figures |
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