Name: Phospho-Syn1 (Ser549) Antibody (PACO24349)
SKU: PACO24349
Availability: OutOfStock

Antibody Name:	Phospho-Syn1 (Ser549) Antibody (PACO24349)
Antibody SKU:	PACO24349
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:	Human, Rat, Mouse
Immunogen:	Peptide sequence around phosphorylation site of serine 549(P-A-S(p)-P-S)derived from Rat Synapsin

Form:	Liquid
Storage Buffer:	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western blot analysis of extract from rat brain and mouse brain tissue using Synapsin(phospho-Ser549) Antibody using.
	Western blot analysis of extracts from Rat brain tissue or calf intestinal phosphatase (CIP), using Synapsin (phospho-Ser549) Antibody.

Background:	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level Greengard, P. (1987) Mol Neurobiol 1, 81-119. Hosaka, M. et al. (1999) Neuron 24, 377-87.
Synonyms:	Syn-1; synapsin I;

UniProt Protein Function:	SYN1: neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported.Protein type: VesicleChromosomal Location of Human Ortholog: Xp11.23Cellular Component: Golgi apparatus; synaptic vesicle; dendrite; cytosol; cell junctionMolecular Function: protein binding; transporter activity; actin binding; protein kinase binding; calcium-dependent protein binding; catalytic activity; ATP bindingBiological Process: synaptic transmission; metabolic process; neurotransmitter secretion; regulation of neurotransmitter secretionDisease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders
UniProt Protein Details:
NCBI Summary:	This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	O88935
NCBI GenInfo Identifier:	19924099
NCBI Gene ID:	6853
NCBI Accession:	NP_008881.2
UniProt Secondary Accession:	O88935,O88935, P09951
UniProt Related Accession:	O88935,P17600
Molecular Weight:	77kDa
NCBI Full Name:	synapsin-1 isoform Ia
NCBI Synonym Full Names:	synapsin I
NCBI Official Symbol:	SYN1
NCBI Official Synonym Symbols:	SYNI; MRX50; SYN1a; SYN1b
NCBI Protein Information:	synapsin-1
UniProt Protein Name:	Synapsin-1
UniProt Synonym Protein Names:	Brain protein 4.1; Synapsin I
Protein Family:	Protein
UniProt Gene Name:	SYN1
UniProt Entry Name:	SYN1_HUMAN