Phospho-STING/TMEM173-S366 Monoclonal Antibody
- SKU:
- CABP1369
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Phospho-STING/TMEM173-S366 Monoclonal Antibody |
| Product Code: | CABP1369 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57910 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | THP-1 |
| Cellular Location: | Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Mitochondrion outer membrane, Multi-pass membrane protein, perinuclear region |
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
| Immunogen: | A synthetic phosphorylated peptide around S366 of human STING1 (NP_938023.1). |
| Sequence: | LISGM |
| Synonyms: | ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta |
| Calculated MW: | 42kDa |
| Observed MW: | 33kDa/40kDa |
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