Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody (PACO04956)
- SKU:
- PACO04956
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Phospho-RPS6KA1/RPS6KA3/RPS6KA2/RPS6KA6 (S221/227/S218/232) Antibody |
| Antibody SKU: | PACO04956 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from human Rsk-1/2/3/4 around the phosphorylation site of S221/227/S218/232. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAP |
| UniProt Protein Function: | p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Translation; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; RSK subfamily Chromosomal Location of Human Ortholog: 1p Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus Molecular Function:protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; protein serine/threonine/tyrosine kinase activity; magnesium ion binding; ATP binding Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; regulation of translation in response to stress; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; cell cycle; signal transduction; protein amino acid phosphorylation; positive regulation of cell growth; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15418 |
| NCBI GenInfo Identifier: | 20178306 |
| NCBI Gene ID: | 6195 |
| NCBI Accession: | Q15418.2 |
| UniProt Secondary Accession: | Q15418,Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2, A6NGG4 A8K9K7, B2RDY8, B7Z5J0, |
| UniProt Related Accession: | Q15418 |
| Molecular Weight: | 72,698 Da |
| NCBI Full Name: | Ribosomal protein S6 kinase alpha-1 |
| NCBI Synonym Full Names: | ribosomal protein S6 kinase, 90kDa, polypeptide 1 |
| NCBI Official Symbol: | RPS6KA1 |
| NCBI Official Synonym Symbols: | RSK; HU-1; RSK1; p90Rsk; MAPKAPK1A |
| NCBI Protein Information: | ribosomal protein S6 kinase alpha-1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1; S6K-alpha 1; S6K-alpha-1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); p90-RSK 1; p90RSK1; p90S6K; ribosomal S6 kinase 1; ribosomal protein S6 kinase alpha 1 |
| UniProt Protein Name: | Ribosomal protein S6 kinase alpha-1 |
| UniProt Synonym Protein Names: | 90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1; RSK-1 |
| Protein Family: | Ribosomal protein S6 kinase |
| UniProt Gene Name: | RPS6KA1 |
| UniProt Entry Name: | KS6A1_HUMAN |
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