Phospho-RB-S780 Monoclonal Antibody (CABP1419)
- SKU:
- CABP1419
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Phospho-RB-S780 Monoclonal Antibody |
| Product Code: | CABP1419 |
| Reactivity: | Human, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52461 |
| Reactivity: | Human, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa+Calyculin A, C6+Calyculin A |
| Cellular Location: | Nucleus |
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S780 of Human RB. |
| Sequence: | Email for sequence |
| Synonyms: | RB, pRb, OSRC, pp110, p105-Rb, PPP1R130, p110-RB1 |
| Calculated MW: | 106kDa |
| Observed MW: | 110kDa |
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