| UniProt Protein Function: | RASGRF1: a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported.Protein type: GEFs, Ras; GEFsChromosomal Location of Human Ortholog: 15q24.2Cellular Component: neuron projection; growth cone; plasma membrane; cytosolMolecular Function: glutamate receptor binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activityBiological Process: regulation of Ras protein signal transduction; synaptic transmission; regulation of Rac protein signal transduction; cell proliferation; long-term memory; small GTPase mediated signal transduction; regulation of synaptic plasticity; positive regulation of Ras protein signal transduction; signal transduction; neurite development; regulation of neuronal synaptic plasticity |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P27671 |
| NCBI GenInfo Identifier: | 24797099 |
| NCBI Gene ID: | 5923 |
| NCBI Accession: | NP_002882.3 |
| UniProt Secondary Accession: | P27671,P27671 |
| UniProt Related Accession: | P27671,Q13972 |
| Molecular Weight: | 143,218 Da |
| NCBI Full Name: | ras-specific guanine nucleotide-releasing factor 1 isoform 1 |
| NCBI Synonym Full Names: | Ras protein-specific guanine nucleotide-releasing factor 1 |
| NCBI Official Symbol: | RASGRF1 |
| NCBI Official Synonym Symbols: | GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1 |
| NCBI Protein Information: | ras-specific guanine nucleotide-releasing factor 1; guanine nucleotide exchange factor; guanine nucleotide-releasing protein; guanine nucleotide-releasing factor, 55 kD; Ras-specific nucleotide exchange factor CDC25; Ras-specific guanine nucleotide-releas |
| UniProt Protein Name: | Ras-specific guanine nucleotide-releasing factor 1 |
| UniProt Synonym Protein Names: | Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide exchange factor CDC25 |
| Protein Family: | CDC25-like phosphatase |
| UniProt Gene Name: | RASGRF1 |
| UniProt Entry Name: | RGRF1_HUMAN |
