Phospho-PTEN-S380/T382/T383 Monoclonal Antibody
- SKU:
- CABP1346
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | Phospho-PTEN-S380/T382/T383 Monoclonal Antibody |
| Product Code: | CABP1346 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55940 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hela, NIH/3T3, PC-12 |
| Cellular Location: | Apical plasma membrane, Cell projection, Cytoplasm, Cytoplasmic side of plasma membrane, Cytosol, Dendritic spine, Extracellular region, Myelin sheath adaxonal region, Neuron projection, Nucleoplasm, Nucleus, plasma membrane, PML body, Postsynaptic density |
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
| Immunogen: | A synthetic phosphorylated peptide around S380 & T383 of human Phospho-PTEN-S380/T382/T383 (NP_000305.3). |
| Sequence: | YSDTT D |
| Synonyms: | BZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del, PTENbeta |
| Calculated MW: | 47kDa |
| Observed MW: | 54kDa |
Related Products
Anti-Phospho-PTEN-S380/T382/383 Antibody (CABP1231)
PTEN Monoclonal Antibody
Human/Mouse/Rat Phospho-PTEN (S380) and Total PTEN PharmaGenie ELISA Kit (SBRS1939)
Human/Mouse/Rat Phospho-PTEN (S380) PharmaGenie ELISA Kit (SBRS1938)
