Phospho-PERK-T982 Monoclonal Antibody (CABP1501)

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SKU:
CABP1501
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC

Description

Product Name:Phospho-PERK-T982 Monoclonal Antibody
Product Code:CABP1501
Reactivity:Human, Mouse
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC58934
Reactivity:Human, Mouse
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:500-1:1000, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:293T+Insulin
Cellular Location:Endoplasmic reticulum membrane

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Immunogen:A synthetic phosphorylated peptide around T982 of human PERK(NP_004827.4).
Sequence:RHTGQ V
Synonyms:PEK, WRS, PERK
Calculated MW:125kDa
Observed MW:170kD
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