| UniProt Protein Function: | Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell Disease: Retinitis Pigmentosa 38 |
| NCBI Summary: | This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12866 |
| NCBI GenInfo Identifier: | 160332297 |
| NCBI Gene ID: | 10461 |
| NCBI Accession: | Q12866.2 |
| UniProt Secondary Accession: | Q12866,Q9HBB4, |
| UniProt Related Accession: | Q12866 |
| Molecular Weight: | 999 |
| NCBI Full Name: | Tyrosine-protein kinase Mer |
| NCBI Synonym Full Names: | MER proto-oncogene, tyrosine kinase |
| NCBI Official Symbol: | MERTK |
| NCBI Official Synonym Symbols: | MER; RP38; c-Eyk; c-mer; Tyro12 |
| NCBI Protein Information: | tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; c-mer proto-oncogene tyrosine kinase |
| UniProt Protein Name: | Tyrosine-protein kinase Mer |
| UniProt Synonym Protein Names: | Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | MERTK |
| UniProt Entry Name: | MERTK_HUMAN |
