Phospho-MDM2-S166 Monoclonal Antibody

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SKU:
CABP1308
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC

Description

Product Name:Phospho-MDM2-S166 Monoclonal Antibody
Product Code:CABP1308
Reactivity:Human, Mouse, Rat
Applications:Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC2909
Reactivity:Human, Mouse, Rat
Tested Applications:IHC-P, ELISA
Key Applications:Immunohistochemistry
Recommended Dilution:IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Cellular Location:Cytoplasm, Nucleus, Nucleolus, Nucleoplasm

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Immunogen:A phospho synthetic peptide corresponding to residues surrounding S166 of Human MDM2.
Sequence:Email for sequence
Synonyms:HDMX, LSKB, hdm2, ACTFS
Calculated MW:55kDa
Observed MW:Refer to figures
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