| UniProt Protein Function: | MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 familyCellular Component: membrane; spindle; intracellular; nucleus; cytosolMolecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; metal ion binding; protein-tyrosine kinase activity; ATP binding; protein kinase activityBiological Process: peptidyl-tyrosine phosphorylation; negative regulation of heterotypic cell-cell adhesion; activation of MAPK activity; heart development; MAPKKK cascade; negative regulation of interleukin-8 biosynthetic process; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; positive regulation of protein metabolic process; positive regulation of cell growth; inhibition of NF-kappaB transcription factor; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | kinase involved in signal transduction in the cell [RGD, Feb 2006] |
| UniProt Code: | Q62862 |
| NCBI GenInfo Identifier: | 2499634 |
| NCBI Gene ID: | 29568 |
| NCBI Accession: | Q62862.1 |
| UniProt Secondary Accession: | Q62862,Q62863, Q62864 |
| UniProt Related Accession: | Q62862 |
| Molecular Weight: | 448 |
| NCBI Full Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
| NCBI Synonym Full Names: | mitogen activated protein kinase kinase 5 |
| NCBI Official Symbol: | Map2k5 |
| NCBI Official Synonym Symbols: | Mek5 |
| NCBI Protein Information: | dual specificity mitogen-activated protein kinase kinase 5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5 |
| UniProt Protein Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase 5; MEK 5 |
| Protein Family: | Dual specificity mitogen-activated protein kinase kinase |
| UniProt Gene Name: | Map2k5 |
| UniProt Entry Name: | MP2K5_RAT |
