Phospho-IRE1-S724 Monoclonal Antibody
- SKU:
- CABP1442
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IHC
Description
| Product Name: | Phospho-IRE1-S724 Monoclonal Antibody |
| Product Code: | CABP1442 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC62282 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IF/ICC 1:50-1:200, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa+CA |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
| Immunogen: | A synthetic phosphorylated peptide around S724 of human IRE1(NP_001424.3). |
| Sequence: | RHSFS |
| Synonyms: | IRE1, IRE1P, IRE1a, hIRE1p |
| Calculated MW: | 110kDa |
| Observed MW: | 130kDa |
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