| UniProt Protein Function: | H1F1: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p21.3Cellular Component: nuclear chromatin; nucleosomeMolecular Function: chromatin DNA binding; protein bindingBiological Process: nucleosome assembly; spermatogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q02539 |
| NCBI GenInfo Identifier: | 18202479 |
| NCBI Gene ID: | 3024 |
| NCBI Accession: | Q02539.3 |
| UniProt Secondary Accession: | Q02539,Q3MJ34 |
| UniProt Related Accession: | Q02539 |
| Molecular Weight: | 21,842 Da |
| NCBI Full Name: | Histone H1.1 |
| NCBI Synonym Full Names: | histone cluster 1, H1a |
| NCBI Official Symbol: | HIST1H1A |
| NCBI Official Synonym Symbols: | H1A; H1.1; H1F1; HIST1 |
| NCBI Protein Information: | histone H1.1 |
| UniProt Protein Name: | Histone H1.1 |
| UniProt Synonym Protein Names: | Histone H1a |
| Protein Family: | Histone |
| UniProt Gene Name: | HIST1H1A |
| UniProt Entry Name: | H11_HUMAN |
