PHKA1/PHKA2 Antibody (PACO04584)
- SKU:
- PACO04584
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PHKA1/PHKA2 Antibody |
| Antibody SKU: | PACO04584 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the N-terminal region of human PHKA1/2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PHKA1; PHKA; Phosphorylase b kinase regulatory subunit alpha; skeletal muscle isoform; Phosphorylase kinase alpha M subunit; PHKA2; PHKLA; PYK; Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase kinase alpha L sub |
| NCBI Summary: | Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010] |
| UniProt Code: | P46020 |
| NCBI GenInfo Identifier: | 169881275 |
| NCBI Gene ID: | 5255 |
| NCBI Accession: | NP_001116142 |
| UniProt Related Accession: | P46020 |
| Molecular Weight: | 129kDa; 135kDa; 137kDa |
| NCBI Full Name: | phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform 2 |
| NCBI Synonym Full Names: | phosphorylase kinase regulatory subunit alpha 1 |
| NCBI Official Symbol: | PHKA1 |
| NCBI Official Synonym Symbols: | PHKA |
| NCBI Protein Information: | phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform |
| UniProt Protein Name: | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform |
| Protein Family: | Phosphorylase b kinase regulatory |
| UniProt Gene Name: | PHKA1 |
| UniProt Entry Name: | KPB1_HUMAN |
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